{"id":4483,"date":"2024-04-14T09:27:59","date_gmt":"2024-04-14T09:27:59","guid":{"rendered":"https:\/\/superdna.nazsoftech.com\/?post_type=article&p=4483"},"modified":"2025-08-28T15:27:38","modified_gmt":"2025-08-28T07:27:38","slug":"the-power-of-polygenic-risk-scores-in-personalised-medicine","status":"publish","type":"article","link":"https:\/\/mysuperdna.com\/zh\/article\/the-power-of-polygenic-risk-scores-in-personalised-medicine\/","title":{"rendered":"The Power of Polygenic Risk Scores in Personalised Medicine"},"content":{"rendered":"

Polygenic risk score (PRS) is an important and increasingly discussed topic in the field of Genetic Testing in Malaysia<\/strong><\/a>.\u00a0 It has the potential to revolutionize personalized medicine by providing valuable insights into an individual\u2019s genetic risk for certain diseases. PRS is calculated using a combination of independent risk variants associated with a particular disorder, as identified through genome-wide association studies (GWAS) [1].<\/p>\n

In the past decade, GWAS has shed light on the role of inherited variants in numerous non-communicable polygenic disorders, including heart disease, cancer, and even personality traits and talents. Unlike single variants, which do not account for disease onset, PRS takes into consideration the cumulative effect of multiple risk alleles or mutations carried by an individual for a specific disease. This personalized score offers a unique disease risk assessment tailored to each person\u2019s genetic makeup [2].<\/p>\n

It is crucial to note that while an individual may have an increased risk for one disease, they may have a low or average risk for other conditions. PRS serves as a valuable tool in routine healthcare practices, enabling the identification and prediction of medical conditions. For instance, by incorporating PRS and genome analysis, some women may discover they have a high genetic risk score for Cancerdetect\u2122 Genetic Test Malaysia<\/strong><\/a> even before the age of 47, the current threshold for mammogram screening [2]. This empowers them to take early interventions and make personalized decisions regarding further testing.<\/p>\n

Research on heart disease involving 290,000 participants revealed that PRS identified 8% of them as having three times the normal risk of experiencing a heart attack. Unfortunately, this elevated risk would not have been detected through normal clinical practice without genetic testing [3]. Similarly, in the case of Alzheimer\u2019s Disease, PRS modification could lead to a difference of up to ten years in disease onset between individuals with the lowest and highest PRS values [4].<\/p>\n

\"Polygenic<\/p>\n